Stop Smoking: More info Wellbutrin Brand: Bupropion Wellbutrin is used to treat major depressive disorder and seasonal affective disorder. More info Wellbutrin SR Brand: Bupropion Wellbutrin SR is a prescription antidepressant that is used in the treatment of depression and smoking. More info Zyban Brand: Bupropion Zyban is used for helping to quit smoking. Patients who wish to quit smoking are given this medicine.